Edited by:

Philippe Bourdeau -- Commission of the European Communities, Brussels, Belgium

Emmanuel Somers - Health and Welfare Canada, Ottawa, Canada

G. Mark Richardson - Health and Welfare Canada, Ottawa, Canada

J. R. Hickman - Health and Welfare Canada, Ottawa, Canada

Prepared by:

Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC)

Published on behalf of the Scientific Committee on Problems of the Environment (SCOPE)

of the International Council of Scientific Unions (ICSU),

and the International Programme on Chemical Safety (IPCS)

of the World Health Organization (WHO),

the United Nations Environment Programme (UNEP),

and the International Labour Organization (ILO)



Chichester, New York, Brisbane, Toronto, Singapore

Copyright 1990: by the Scientific Committee on Problems of the Environment (SCOPE)

Click on a chapter number to open pdf.

Title Pages

Table of Contents

Forword and Preface


Part A - Joint Report

Chapter 1. Introduction, General Conclusions, and Recommedations

Chapter 2. Non-specialized Mammalian Cell Cultures for Toxicity Testing

Chapter 3. Methods to Detect Toxic Effects in Specific Mammalian Organs and Physiological Systems

Chapter 4. Methods to Predict Toxicity

Chapter 5. Short-term Tests in Ecotoxicology

Part B - Contributed Papers

Chapter 6. Conceptual Approaches to Methodology Development - Alan M. Goldberg and Andrew N. Rowan

Chapter 7. Toxicity Tests with Mammalian Cell Cultures - B. Ekwall, V. Silano, A. Paganuzzi-Stammati and F. Zucco

Chapter 8. The Gastrointestinal Tract and Short-term Toxicity Tests - Donald Barltrop and Martin J. Brueton

Chapter 9. Specific Organ/System Toxicity: the Liver - James W. Bridges

Chapter 10. The Developing Kidney in Toxicity Tests - Lauri Saxen

Chapter 11. The Skin: Predictive Value of Short-term Toxicity Tests - Raymond R. Suskind

Chapter 12. Evaluation and Prediction of Chemical Toxicity using Haematopoietic Cell Renewal Systems - T.M. Fliedner, H. Heit and G. Pabst

Chapter 13. Short-term Tests for Neurotoxicity - Silvio Garattini

Chapter 14 . Methods for Assessing the Effects of Chemicals on the Endrocrine System - J.H. Clark and F.X.R. van-Leeuwen

Chapter 15. Methods for Assessing the Effects of Chemicals on the Immune System - J.G. Vos and J.H. Dean

Chapter 16. Potential Short-term Tests to Detect Chemicals Capable of Causing Reproductive and Developmental Dysfunction - Carlton H. Nadolney, Neil Chernoff, Robert L. Dixon, Kundan S. Khera, Ralf Krowke, Boris V. Leonoy, Diether Neubert and Sonia Tabacova

Chapter 17. Toxicological versus Ecotoxicological Testing - Guido Persoone and James Gillett

Chapter 18. Possibilities and Limitations of Predictions from Short-term Tests in the Aquatic Environment - Guido Persoone, David Calamari and Peter Wells

Chapter 19. Possibilities and Limitations of Short-term Tests for Ecotoxicologic Effects: Terrestrial Approaches - James W. Gillett

Chapter 20. Predicting Safe Levels of Chemicals - I.V. Sanockij

Chapter 21. Computer-aided Chemical Structure-handling Techniques in Structure-Activity Relationship Systems - Josef Friedrich, Wolfgang Schubert and Ivar Ugi